中国科技期刊卓越行动计划推介：Sci China Life Sci

摘要：Xiaodong Mo, Weilong Zhang, Guomei Fu, Yingjun Chang, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Mengzhu Shen, Qiuxia Wei, C

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Cover Article

A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development

Lin Zhang, Shi-Meng Cao, Hao Wu, Meng Yan, Jinsong Li, Ling-Ling Che

SCIENCE CHINA Life Sciences 67(11), 2024, 2297-2306

FROM CAS & CAE MEMBERS

Profile

Profile of Dr. Xiao-Jun Huang

SCIENCE CHINA Life Sciences 67(11), 2024, 2307-2308

Research Paper

Single-cell immune landscape of measurable residual disease in acute myeloid leukemia

Xiaodong Mo, Weilong Zhang, Guomei Fu, Yingjun Chang, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Mengzhu Shen, Qiuxia Wei, Changjian Yan, Xiaojun Huang

SCIENCE CHINA Life Sciences 67(11), 2024, 2309-2322

Review

COVID-19 vaccine updates for people under different conditions

Yijiao Huang, Weiyang Wang, Yan Liu, Zai Wang, Bin Cao

SCIENCE CHINA Life Sciences 67(11), 2024, 2323-2343

Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation

Qian Hao, Jinfeng Li, Leng-Siew Yeap

SCIENCE CHINA Life Sciences 67(11), 2024, 2344-2353

Role of macrophages in aortic dissection pathogenesis: insights from preclinical studies to translational prospective

Shiyi Li, Weiguo Fu, Lixin Wang

SCIENCE CHINA Life Sciences 67(11), 2024, 2354-2367

Research Paper

Whole-genome sequencing identifies novel genes for autism in Chinese trios

Suhua Chang, Jia Jia Liu, Yilu Zhao, Tao Pang, Xiangyu Zheng, Zhirui Song, Anyi Zhang, Xuping Gao, Lingxue Luo, Yanqing Guo, Jing Liu, Li Yang, Lin Lu

SCIENCE CHINA Life Sciences 67(11), 2024, 2368-2381

Activation of the PGC-1α-mediated mitochondrial glutamine metabolism pathway attenuates female offspring osteoarthritis induced by prenatal excessive prednisone

Qingxian Li, Fan Zhang, Yongguo Dai, Liang Liu, Liaobin Chen, Hui Wang

SCIENCE CHINA Life Sciences 67(11), 2024, 2382-2397

The single-cell transcriptomic landscape of the topological differences in mammalian auditory receptors

Xiangyu Ma, Xin Chen, Yuwei Che, Siyao Zhu, Xinlin Wang, Shan Gao, Jiheng Wu, Fanliang Kong, Cheng Cheng, Yunhao Wu, Jiamin Guo, Jieyu Qi, Renjie Chai

SCIENCE CHINA Life Sciences 67(11), 2024, 2398-241

RpL38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis

Yang Fang, Fengchao Zhang, Fangzhen Zhao, Jiajia Wang, Xinkai Cheng, Fei Ye, Jiayu He, Long Zhao, Ying Su

SCIENCE CHINA Life Sciences 67(11), 2024, 2411-2425

Temperature regulates negative supercoils to modulate meiotic crossovers and chromosome organization

Yingjin Tan, Taicong Tan, Shuxian Zhang, Bo Li, Beiyi Chen, Xu Zhou, Ying Wang, Xiao Yang, Binyuan Zhai, Qilai Huang, Liangran Zhang, Shunxin Wang

SCIENCE CHINA Life Sciences 67(11), 2024, 2426-2443

Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus

Kun Zhang, Xu Huang, Chongqing Wang, Xidan Xu, Xiaowei Xu, Xiaoping Dong, Qingwen Xiao, Jinhai Bai, Yue Zhou, Zhengkun Liu, Xinyi Deng, Yan Tang, Siyang Li, Enkui Hu, Wanjing Peng, Ling Xiong, Qinbo Qin, Shaojun Liu

SCIENCE CHINA Life Sciences 67(11), 2024, 2444-2458

Multi-omics analysis reveals the genetic and environmental factors in shaping the gut resistome of a keystonerodentspecies

Guoliang Li, Dong Zhu, Chaoyuan Cheng, Haiyan Chu, Fuwen Wei, Zhibin Zhang

SCIENCE CHINA Life Sciences 67(11), 2024, 2459-2470

Versatile and efficient mammalian genome editing with Type I-C CRISPR System of Desulfovibrio vulgaris

Pan Li, Dingcai Dong, Fei Gao, Yuyang Xie, Honglin Huang, Siwei Sun, Zhao Ma, Cheng He, Jinsheng Lai, Xuguang Du, Sen Wu

SCIENCE CHINA Life Sciences 67(11), 2024, 2471-2487

6-Phosphogluconate dehydrogenase 2 bridges the OPP and shikimate pathways to enhance aromatic amino acid production in plants

Qian Tang, Yuxin Huang, Zhuanglin Shen, Linhui Sun, Yang Gu, Huiqing He, Yanhong Chen, Jiahai Zhou, Limin Zhang, Cuihuan Zhao, Shisong Ma, Yunhai Li, Jie Wu, Qiao Zhao

SCIENCE CHINA Life Sciences 67(11), 2024, 2488-2498

Shifts in reproductive strategies in the evolutionary trajectory of plant lineages

Xin-Jian Zhang, Xian-Han Huang, Jacob B. Landis, Quan-Sheng Fu, Jun-Tong Chen, Peng-Rui Luo, Li-Juan Li, Heng-Yi Lu, Hang Sun, Tao Deng

SCIENCE CHINA Life Sciences 67(11), 2024, 2499-2510

MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber’s hereditary optic neuropathy

Rui Wang, Feixiang Bao, Manjiao Lu, Xiaoyun Jia, Jiahui Xiao, Yi Wu, Qingjiong Zhang, Xingguo Liu

SCIENCE CHINA Life Sciences 67(11), 2024, 2511-2519

Insight

Huangjing is not only a good medicine but also an affordable healthy diet

Donghong Chen, Dun Si, Jingjing Liu, Jinping Si

SCIENCE CHINA Life Sciences 67(11), 2024, 2520-2522

Letter to the editor