摘要：▸Cancer Innovation《肿瘤学创新（英文）》是由教育部主管，清华大学主办，清华大学出版社与 Wiley战略合作下出版的一本跨学科的开放获取（OA）英文期刊。
▸Cancer Innovation《肿瘤学创新（英文）》是由教育部主管，清华大学主办，清华大学出版社与 Wiley战略合作下出版的一本跨学科的开放获取（OA）英文期刊。
▸Cancer Innovation是一本聚焦于肿瘤医学前沿的英文期刊，致力于促进医学与工学、信息学、药学、生物学等多学科交叉，引导肿瘤专业与心血管、呼吸、神经、生殖等跨专业融合。
▸Cancer Innovation已入选“2022年中国科技期刊卓越行动计划高起点新刊项目”，已被国际知名数据库ESCI、PMC、Scopus、DOAJ、CAS（美国化学文摘）收录。
▸Cancer Innovation名誉主编由中国工程院院士、国家癌症中心/中国医学科学院肿瘤医院国家新药（抗肿瘤）临床研究中心主任徐兵河院士，中国工程院院士、北京大学国际癌症研究院院长、北京大学健康医疗大数据国家研究院院长詹启敏院士，以及中国工程院院士、中科院上海药物研究所丁健院士共同担任，主编由国家癌症中心/中国医学科学院肿瘤医院马飞教授担任。
▸期刊发表论文类型多元，包括Original Article, Review, Clinical Guideline, Technical Report, Case Report, Commentary, News, Study Protocol, Meta-Analysis, Letter与Editorial。
第4卷第1期(2025.2)
注：本文中*表示通讯作者
REVIEW
01
标题
Biological function and mechanism of NAT10 in cancer
NAT10的生物学功能及在癌症中的作用机制
作者
Yufeng Han, Xinxin Zhang, Lei Miao, Huiran Lin, Zhenjian Zhuo*, Jing He*, Wen Fu*
图片摘要
N-acetyltransferase 10 (NAT10) is a nucleolar acetyltransferase with an acetylation catalytic function and can bind various protein and RNA molecules. As the N4-acetylcytidine (ac4C) “writer” enzyme, NAT10 is reportedly involved in a variety of physiological and pathological activities. Currently, the NAT10-related molecular mechanisms in various cancers are not fully understood. In this review, we first describe the cellular localization of NAT10 and then summarize its numerous biological functions. NAT10 is involved in various biological processes by mediating the acetylation of different proteins and RNAs. These biological functions are also associated with cancer progression and patient prognosis. We also review the mechanisms by which NAT10 plays roles in various cancer types. NAT10 can affect tumor cell proliferation, metastasis, and stress tolerance through its acetyltransferase properties. Further research into NAT10 functions and expression regulation in tumors will help explore its future potential in cancer diagnosis, treatment, and prognosis.
如何引用
Han Y, Zhang X, Miao L, Lin H, Zhuo Z, He J, et al. Biological function and mechanism of NAT10 in cancer. Cancer Innov. 2025; 3:e154.
ORGINAL ARTICLE
02
标题
Identification of significant single-nucleotide polymorphisms associated with breast cancer recurrence and metastasis using GWAS
使用GWAS鉴定与乳腺癌复发和转移相关的显著单核苷酸多态性研究
作者
Shujuan Sun, Sha Yin, Jie Huang, Dongdong Zhou, Qiaorui Tan, Xiaochu Man, Wen Wang, Jiale Zhang, Huihui Li*
图片摘要
Background
Identification of risk genes and loci associated with the recurrence and metastasis of breast cancer (BC) is of utmost importance. Genome-wide association studies (GWASs) represent valuable tools for identifying the disease risk associated with a given single-nucleotide polymorphism (SNP); they offer significant insights into the disease progression mechanism by analyzing SNP information of the entire genome. Though GWAS has already identified several genetic susceptibility SNPs for BC, their significance in the recurrence and metastasis of this cancer remains unclear. Here, we used a GWAS approach to identify SNPs specifically associated with the risk of BC recurrence and metastasis.
Methods
This study adopted a two-stage GWAS approach. In the first stage, 97 pairs of BC patients with or without recurrence and metastasis, treated at the Shandong Cancer Hospital and Institute from November 2013 to April 2014, were identified using propensity score matching. DNA extracted from the patient peripheral blood was then subjected to Illumina ASA chip analysis for genome-wide SNP detection. In the second stage, the findings were verified in a validation set of 854 BC patients recruited at the same hospital from May 2014 to June 2015. SNP genotyping was performed using time-of-flight mass spectrometry. The SNP loci and their corresponding genes and pathways were analyzed using the DAVID (https://david.ncifcrf.gov/) online enrichment analysis tool.
Results
Based on the GWAS results, 191 SNP-related genes significantly associated with BC recurrence and metastasis were identified as expression quantitivative trait loci (p
Conclusion
Our study suggests that the SNPs rs10108514, rs12920540, rs4273077, and rs4730155 are correlated with the risk of BC recurrence and metastasis, potentially by being implicated in glutamatergic synaptic transmission, calcium signaling, and insulin secretion pathways.
如何引用
Sun S, Yin S, Huang J, Zhou D, Tan Q, Man X, et al. Identification of significant single-nucleotide polymorphisms associated with breast cancer recurrence and metastasis using GWAS. Cancer Innov. 2025; 4:e142.https://doi.org/10.1002/cai2.142
03
标题
lncRNA TCONS_00251376 promotes the proliferation and migration of gastric cancer cell through upregulating ETV1
lncRNA tcon_00251376通过上调ETV1促进胃癌细胞的增殖和迁移研究
作者
Dengfeng Ren, Fuxing Zhao, Jinming Li, Xinjian Guo, Xinfu Ma, Yonghui Zheng, Guoshuang Shen*, Jiuda Zhao*
图片摘要
Background
Although there have been significant advancements in the treatment modalities for gastric cancer (GC) in recent years, the overall prognosis remains poor, particularly for individuals in advanced stages. The absence of a sensitive tumor marker in GC is a crucial factor contributing to this challenge.
Methods
Our study focused on investigating a newly discovered long noncoding RNA (lncRNA) known as TCONS_00251376, which has been confirmed to exhibit differential expression in GC compared to adjacent tissues. To further validate these expression differences, we collected 22 pairs of GC and adjacent noncancerous tissues. Subsequent cell function experiments and animal studies were conducted to elucidate the role and underlying mechanisms of lncRNA TCONS_00251376 in the development of GC.
Results
The study revealed a significant upregulation of lncRNA TCONS_00251376 in cancer tissues (p
Conclusions
Therefore, our findings suggest that lncRNA TCONS_00251376 functions as an oncogenic lncRNA, promoting tumorigenesis and progression by regulating the expression of ETV1 gene. This highlights its potential as an effective target for treating GC.
如何引用
Ren D, Zhao F, Li J, Guo X, Ma X, Zheng Y, et al. lncRNA TCONS_00251376 promotes the proliferation and migration of gastric cancer cell through upregulating ETV1. Cancer Innov. 2025; 4:e156.
04
标题
Expression pattern and prognostic significance of aldehyde dehydrogenase 2 in lung adenocarcinoma as a potential predictor of immunotherapy efficacy
醛脱氢酶2在肺腺癌中的表达模式及其预后意义作为免疫治疗疗效的潜在预测因子
作者
Silvia Baldari*, Annalisa Antonini, Giuliana Di Rocco, Gabriele Toietta*
图片摘要
Background
The incidence of alcohol-associated cancers is higher within Asian populations having an increased prevalence of an inactivating mutation in aldehyde dehydrogenase 2 (ALDH2), a mitochondrial enzyme required for the clearance of acetaldehyde, a cytotoxic metabolite of ethanol. The role of alcohol consumption in promoting lung cancer is controversial, and little attention has been paid to the association between alcohol drinking and pulmonary ALDH2 expression.
Methods
We performed a comprehensive bioinformatic analysis of multi-omics data available in public databases to elucidate the role of ALDH2 in lung adenocarcinoma (LUAD).
Results
Transcriptional and proteomic data indicate a substantial pulmonary expression of ALDH2, which is functional for the metabolism of alcohol diffused from the bronchial circulation. ALDH2 expression is higher in healthy lung tissue than in LUAD and inhibits cell cycle, apoptosis, and epithelial–mesenchymal transition pathways. Moreover, low ALDH2 mRNA levels predict poor prognosis and low overall survival in LUAD patients. Interestingly, ALDH2 expression correlates with immune infiltration in LUAD.
Conclusions
A better understanding of the role of ALDH2 in lung tumor progression and immune infiltration might support its potential use as a prognostic marker and therapeutic target for improving immunotherapeutic response.
如何引用
Baldari S, Antonini A, Di Rocco G, Toietta G. Expression pattern and prognostic significance of aldehyde dehydrogenase 2 in lung adenocarcinoma as a potential predictor of immunotherapy efficacy. Cancer Innov. 2025; 3:e149.
05
标题
Subtype-specific transcription factors affect polyamine metabolism and the tumor microenvironment in breast cancer
亚型特异性转录因子影响乳腺癌多胺代谢和肿瘤微环境
作者
Qi Song, Yixuan Wang, Sen Liu*
图片摘要
Background
Polyamines play important roles in cell growth and proliferation. Polyamine metabolism genes are dysregulated in various tumors. Some polyamine metabolism genes are regulated by transcription factors. However, the transcription factors that regulate polyamine metabolism genes have not been completely identified. Additionally, whether any of the transcriptional regulations depend on tumor heterogeneity and the tumor microenvironment has not been investigated.
Methods
We used bulk RNA-seq data to identify dysregulated polyamine metabolism genes and their transcription factors across breast cancer subtypes. Genes highly correlated with polyamine changes were obtained, and their subtype-specific expressions were checked in tumor microenvironment cells using single-cell RNA (scRNA)-seq data. Gene Ontology enrichment analysis was used to explore their molecular functions and biological processes, and survival analysis was used to examine the impact of these genes on therapeutic outcome.
Results
We first analyzed the dysregulation of polyamine synthesis, catabolism, and transport in four breast cancer subtypes. Genes such as AGMAT and CAV1 were dysregulated across all subtypes, while APRT, SAT1, and other genes were dysregulated in the more lethal subtypes. Among the dysregulated genes of polyamine metabolism, we focused on three genes (SRM, APRT, and SAT1) and identified their transcription factors (SPI1 and IRF1 correspond to SAT1, and IRF3 corresponds to SRM and APRT). With scRNA-seq data, we verified that these three transcription factors also regulated these three polyamine metabolism genes in the tumor microenvironment. Both bulk RNA-seq and scRNA-seq data indicated that these genes were specifically upregulated in high-risk breast cancer subtypes, such as the basal-like type. High expression of these genes corresponded to worse outcomes in the basal-like subtype under chemotherapy and radiation treatment.
Conclusion
Our work identified three subtype-specific transcription factors that regulate three polyamine metabolism genes in high-risk breast cancer subtypes and the tumor microenvironment. Our results deepen the understanding of the role of polyamine metabolism in breast cancer and may help the clinical therapy of advanced breast cancer subtypes.
如何引用
Song Q, Wang Y, Liu S. Subtype-specific transcription factors affect polyamine metabolism and the tumor microenvironment in breast cancer. Cancer Innov. 2025; 4:e138.
06
标题
Effectiveness of ultrasound-guided vacuum-assisted excision for treating benign breast lesions
超声引导下真空辅助切除术治疗乳腺良性病变的有效性研究
作者
Xuanni Tan, Juncheng Xuhong, Xiang Ai, Qin Niu, Jing Liu, Yi Zhang*, Xiaowei Qi*, Jun Jiang*
图片摘要
Background
Ultrasound‑guided vacuum-assisted excision (UGVAE) and breast biopsy are widely used for the diagnosis and treatment of both benign and suspicious breast lesions. In this retrospective study, we aimed to determine the safety of UGVAE for benign breast lesions and provide guidance for clinical practice.
Methods
We analyzed clinical and pathological data of female patients who had undergone UGVAE between January 2015 and December 2017 at our institution. All breast lesions were categorized according to the Breast Imaging Reporting and Data System (BI-RADS) before performing UGVAE.
Results
In our study cohort, UGVAE was used to resect 10,378 breast lesions from 5789 patients, and selected clinical and histopathological data were analyzed. The most common adverse events were postoperative bleeding (0.24%) and skin hypersensitivity (0.67%). The residual lesion rate was 2.27%. Fibroadenomas accounted for most of the benign lesions (7932 of 10,193; 77.82%). Breast cancer was diagnosed in 150 lesions from 128 patients. Multivariable binary logistic regression analyses showed that older age (odds ratio [OR] = 2.034, 95% confidence interval [CI]: 1.668–2.480, p p p = 0.001) were associated with an increased likelihood of breast cancer. Ninety-six patients with breast cancer had undergone follow-up treatment, achieving a 3-year disease-free survival rate of 97.2% and a 3-year overall survival rate of 100%.
Conclusions
UGVAE is a safe and effective means of removing benign breast lesions, causing minimal postoperative trauma and fewer complications compared with open surgery. Moreover, UGVAE had little impact on the follow-up treatment and survival of patients diagnosed with breast cancer.
如何引用
Tan X, Xuhong J, Ai X, Niu Q, Liu J, Zhang Y, et al. Effectiveness of ultrasound-guided vacuum-assisted excision for treating benign breast lesions. Cancer Innov. 2025; 4:e158.
07
标题
Mitigating ibrutinib-induced ventricular arrhythmia and cardiac dysfunction with metformin
二甲双胍减轻依鲁替尼引起的室性心律失常和心功能障碍
作者
Pengsha Li, Daiqi Liu, Pan Gao, Ming Yuan, Zhiqiang Zhao, Yue Zhang, Zandong Zhou, Qingling Zhang, Meng Yuan, Xing Liu, Gary Tse, Guangping Li, Qiankun Bao, Tong Liu*
图片摘要
Background
Ibrutinib is a first-line drug that targets Bruton's tyrosine kinase for the treatment of B cell cancer. However, cardiotoxicity induced by ibrutinib is a major side effect that limits its clinical use. This study aimed to investigate the mechanism of ibrutinib-induced cardiotoxicity and evaluate the protective role of metformin.
Methods
The study utilized male C57BL/6 J mice, which were administered ibrutinib at a dosage of 30 mg/kg/day via oral gavage for 4 weeks to induce cardiotoxicity. Metformin was administered orally at 200 mg/kg/day for 5 weeks, starting 1 week before ibrutinib treatment. Cardiac function was assessed using echocardiography and electrophysiological studies, including surface electrocardiography and epicardial electrical mapping. Blood pressure was measured using a tail-cuff system. Western blot analysis was conducted to evaluate the activity of the PI3K-AKT and AMPK pathways, along with apoptosis markers.
Results
C57BL/6 J mice were treated with ibrutinib for 4 weeks to assess its effect on cardiac function. We observed that ibrutinib induced ventricular arrhythmia and abnormal conduction while reducing the left ventricular ejection fraction. Furthermore, pretreatment with metformin reversed ibrutinib-induced cardiotoxicity. Mechanistically, ibrutinib decreased PI3K-AKT activity, resulting in apoptosis of cardiomyocytes. Administration of metformin upregulated AMPK and PI3K-AKT activity, which contributed to the improvement of cardiac function.
Conclusion
The study concludes that metformin effectively mitigates ibrutinib-induced cardiotoxicity, including ventricular arrhythmia and cardiac dysfunction, by enhancing AMPK and PI3K-AKT pathway activity. These findings suggest that metformin holds potential as a therapeutic strategy to protect against the adverse cardiac effects associated with ibrutinib treatment, offering a promising approach for improving the cardiovascular safety of patients undergoing therapy for B cell cancers.
如何引用
Li P, Liu D, Gao P, Yuan M, Zhao Z, Zhang Y, et al. Mitigating ibrutinib-induced ventricular arrhythmia and cardiac dysfunction with metformin. Cancer Innov. 2025; 4:e151. https://doi.org/10.1002/cai2.151
CASE REPORT
08
标题
A rare primary cutaneous myoepithelial carcinoma in the axilla accompanied by lymph node metastasis: A case report
腋窝原发性皮肤肌上皮癌伴淋巴结转移病例1例
作者
Xudong Zhu, Shenglong Li*
图片摘要
Primary cutaneous myoepithelial carcinoma is an extremely rare tumor, and to the best of our knowledge, it has never been reported to occur in the axilla. Furthermore, the pathological and clinical factors of cutaneous myoepithelial carcinoma are poorly understood and may considerably affect prognosis and treatment. Here, we report a case of a 44-year-old male patient who was diagnosed with primary cutaneous myoepithelial carcinoma in the axilla accompanied by extensive lymph node metastasis. After an enlarged resection of the left axillary mass, axillary lymph node dissection, and the administration of postoperative chemotherapy and local radiotherapy, there were no signs of tumor recurrence or metastasis. At the time of manuscript preparation, the patient was recurrence-free. This case may contribute to the clinical management, diagnosis, and treatment of primary cutaneous myoepithelial carcinoma.
如何引用
Zhu X, Li S. A rare primary cutaneous myoepithelial carcinoma in the axilla accompanied by lymph node metastasis: a case report. Cancer Innov. 2025; 4:e157. https://doi.org/10.1002/cai2.157
来源：科创中国
