摘要：Xiaomei Feng,†XiangyeLi,† Ning Zhang, Lizhi Zhang,FenggangSun, Hui Liu,ZengdianZhao, andXinjinLi*

转自：康龙化成

Cross-Electrophile Coupling of Aryl Chlorides with Alkyl Chlorides Using Rotating Magnetic Field and Metal Rods

Xiaomei Feng,†Xiangye Li,† Ning Zhang, Lizhi Zhang, Fenggang Sun, Hui Liu, Zengdian Zhao, and Xinjin Li*

School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong 255000, China;

—J. Am. Chem. Soc., 2025

Recommended by Murong Xu_MC3

KEYWORDS: electromagnetic chemistry, magnetoredox, XEC, (反应类型) C(sp3)-C(sp2) (成键类型), Aryl chlorides (原料), rotating magnetic field and metal rods (其他)

ABSTRACT: The pursuit of sustainable and environmentally benign methods and techniques continues to challenge organic chemists. Herein, we report the development of a novel approach in which electromagnetic induction could participate in the coupling of organic chlorides using a rotating magnetic field and metal rods. In particular, wedescribe the application of this strategy to the nickel-catalyzed cross-electrophile coupling of aryl chlorides with alkyl chlorides. Using these abundant and commercially available organochlorides, such a system allows reactions to proceed with a broader scope than the current protocols under mild conditions.

Nickel-Catalyzed Cross-Electrophile Coupling of Organic Chlorides

Control Reactions of Optimized Conditions

Scope of Cross-Electrophile Coupling of Aryl Chlorides with Alkyl Chlorides

Proposed Mechanism

Experimental setup and its profile diagram

Prof.Xinji Li et alhave developed the cross-electrophile coupling of aryl chlorides with alkyl chlorides via the merger of magnetoredox and nickel catalysis by using a rotating magnetic field and steel rods. This magnetoredox-based methodology, with a broader scope than current protocols, allows access to highly functionalized C(sp2)−C(sp3)coupled products under mild conditions. Mechanistic studies demonstrate that electron transfer via electromagnetic induction could promote the reduction process to accomplish the catalytic cycle. The novel approach enables chemoselective C−C couplings through the multifaceted regulation of magnetic intensity, rod size, and rotating frequency.

来源：新浪财经