摘要：·1、drjacobtorus，as a kidney scientist，i mean you study kidneys and their function and kidney disease pretty much all day every day

·1、drjacobtorus，as a kidney scientist，i mean you study kidneys and their function and kidney disease pretty much all day every day，who's the kind of person that really should be limiting protein consumption。

·2、uh so from my research and experience，the main individuals are late stage chronic cany disease uh and people that so they might have a um stage four，which is the you know the farthest progression and stage three b。

·3、i think those are the ones we start to see protein in the urine，those are like the individuals that are starting to get to the issue with filtration specifically and so you can have all these problems with getting rid of excess ammonia or urea and that's when things start to get iffy about overproducing those nitrogen compounds。

·4、so where did all this stuff come from with regards to you should limit your protein intake for kidney health or better yet just for regular people。

·5、if you consume too much protein，it's bad for your kidneys like a where do that come from b，how does that actually work，what does that actually look like what does protein really do when it comes down to the kidneys and what would maybe the taller will upper him out generally be。

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so i wish i could give you the full history.

but i know a few of the details about where this comes from so e protein.

protein makes ammo the has nitrogen in it so the nitrogen makes it ends up as urea.

and then you can also make ammonia from that over acidification of is a is an issue.

so if you eat a lot of protein one of the issues is that you might make a lot of memonia.

and then that'll end up causing the acidification of the urine.

so the kidney being sitified is a problem.

like that's that kind of established that umover certification causes all sorts of problems in function.

and it's why like supplementing with things like my carbonate is good.

because you kind of raise the ph of the urine and the kidney function.

so that seems to be good.

because the optimal ph is you know seven point two between six point a and seven point two.

it seems to be really good for kidneys so six seven point two even seems better.

like mitochondrial work better everything just seems to have a higher flow rate.

but if you acidify you start to decrease all the metabolic machinery start to not work as well.

as it gets over acidified so protein is associated with that function that issue.

so you eat all protein you get a lot of acidification.

so that's a big part of it.

so that's the i think one of the stories the other one is that proteinsshows up in the urine of late stage kinetazy.

so if you have protein uria that's like means that the cells that are responsible for preventing the like they're filtering out the urine.

they are no longer than a lot of acidification.

so if you eat a lot of protein one of of the issues is that you might make a lot of memonia.

so the the kidney being sitified is a problem.

like that's kind

protein starts it can make its way from the blood into the urine and then it just shows up as it shows up on a test and they're saying okay well now that you're showing deterioration of kidney function you know no longer filtering properly and so then i think that alone people hear protein yeah and then protein you know it gets a so it just dies for preverse causation yeah is associated with that but really what you're seeing is albumin which is just like the major blood component protein that's just showing up in the urine i don't it's not like a direct corlish in between the food the protein you eat and the albumen in your blood they're not related in that way just that i think that the state they both say protein just like fat is bad because fat has the word fat in it yeah just like one of those types of things yeah eating fat doesn't necessarily mean that you have high the ldl or that yeah it would make you fat necessarily so this we have this just this naming convention that i think that also is confusing and then there was some research that was i think one study in the seventy i always forget this part of the story but it's there was one research that indicated that maybe the protein intake was bad for kidneys but then that was like not very well done and then it kind of just stayed as dogma throughout time and as data has been you know grown and grown is find that protein intake does not seem to deteriorate kidney function if it's like a normal mounts so you know twenty twenty five percent protein intake is like normal like that just like a normal protein intake does not seem to lead to um kinney function loss there have been some studies where they've looked at very high protein intakes and it seems like there's another effect called hyper filtration that occurs so if you eat a bowl of protein you get this constriction of the arterials around the nikolamerilus so it's like this blood supply that feeds the filtering unit of the kidney and that is related to the amount of protein that's just the stud just been eaten so if you eat a big ball as a protein it actually causes constriction and then increases the filtration rate

so you get this thing called hyper filtration，but that is that's like the thing that people worry about they worry about this effect primarily when they talk about the excess protein。

so if you eat some protein the hyper filtration occurs transiently that's normal。

you get this transient hyper filtration，it's not the same as the hypofiltration that occurs when you have like say a high blood pressure or some other a vascular disease that occurs where it causes constriction or some other like just from high blood pressure alone。

can cause this hyper filtration effect that's one of the signs of late stage kidney disease is that you get hyper filtration。

so they're associating the acute protein response for hyperfiltration with the chronic kidney disease hyperfiltration symptom。

and so then that's the other portion of the story that causes protein to be demonized for kidneys。

so you kind of end up with these like these all these little stories that come together and they make protein be bad for kidneys。

so what would it tolerable or interesting say tolerable but i mean when you see at least in the literature as being the amount where this hyper filtration even starts like is it a pretty significant bolus of protein that you'd have to take in。

yeah i think if you do like a i mean if you eat a chicken breast i think you would experience some form of hyper filtration transit throughout all the chicken breast。

i think just like a 30 gram 40 grams of protein would be enough to cause a like an elevation of just this just that but again it's transient yeah because for just the period time that amino acids are elevated in the blood that dirt following that bolus and then you it kind of goes back to its normal amount。

so it's not like a lot required。

but again it seems like it's a normal function of the biology of the kidney that it just responds in that way。

so and that's even in that that a cute kind of time for him and it's not particularly stressful on the kidney from my using。

i don't think so i mean it seems to be normal。

i would not know if you if they called stressle but i think the concern is that repeatedly activating that hyper filtration response might put stress on the kidneys。

yeah i mean if you eat a chicken breast i think would experience some form of hyper filtration transit throughout all the chicken breast。

i think just like a 30 gram 40 grams of protein would be enough to cause a like an elevation of just this just that but it's transient yeah because for just the time amino acids are elevated in the

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it looks like protein was independent of the progression so the people that had normal protein consumption throughout the they were not restricting they still progress the same as anybody else did and they compared it to restricting protein and it didn't do it restricted actually they didn't matter and they probably had it were worse off because they're going to be losing muscle mass during that period of time that they're restricting it is there any kind of feedback that you're aware of in terms of metabolic health let's say someone that what i'm trying to look at is if someone eats adequate amount of protein as they're aging and they maintain adequate muscle mass and consequently adequate metabolic health as a result of having a glucose sink can sort of just that extra metabolic health is there a link between better metabolic health and better function like where they operate really independently yeah i assume so because i just from what i know about the kidneys they seem to be you know very responsive to access glucose like glu like over too much glucose seems to be really bad for the kidney that because it's all sorts of all sorts of problems so having a glucose sink is really important is you get older like you know if your muscle mass starts to decrease you're just losing a disposal right like it was nowhere for all that extra glucose to go so it ends up glycating things so that's like i think we talked about this before about the the glycation of proteins that causes a lot of problems in the kidneys that's a that isn't one of the big issues of over time like excess glucose causes the collocation and then insulin resistance is another big problem for kidneys let's clear up the collocation piece really piece really quick though cause i feel like that's that gets confusing and i know we've talked about another video but like the excess protein isn't causing glycation of the proteins cause people get confused with that they're like oh school should i should limit my protein because the protein is gonna get clocated that maybe just explain that real quick so the glycations occurring on like cellular proteins so like you might have you might have receptors or proteins that are sticking out into the you know either interacting with the blood or interacting with like the fil trader and this example the kidney

·and if you have high glucose you can have things attaching to those extracellular receptors and it can change their function because there already have glycations on them like that were put there by the cell the cell makes every protein that is expressed on the outside of a cell has glycation on it and so if you have a lot and they're specific patterning so the pattern is very specific to that cell and what it's doing and it did it purposefully。

·and if you have these high glucose levels you can have the non enzymatic edition of these molecules onto those proteins and it can actually change like the code that's on those proteins to maybe say that they're not self any longer or that they they no longer dock to the proper proteins are supposed to bind to so that's the glycation that we're concerned with and you can also have that occur on proteins intercilially or on different sides of the you know like on the basement membrane as well the cell okay yeah so it's not consuming carbohydrates with protein causing clication in the no i've not heard that one oh you hear it all in the comment section okay yeah you're around people that are in the lab and probably you know have a basic understanding of that it's usually either people that have been misled or trolls that okay yeah i've not heard that one before but yeah it's not gonna be the stuff that you're eating it's gonna i don't think there's a sufficient time for that glycation occur there could be stuff that you're eating when it comes down to you know insulin resistance and glucose spikes but there could be like malliard reaction as a referencing too probably because like malliard reaction you know you're cooking and you're caramelizing it yes exactly then you could have some in non enzymatic addition you have all sorts of things being produced there but if you're cooking like in a sugar sauce you're putting your your meat with sugar and then you cook it you're causing a reaction and then yes you could clikate those those proteins that way that could change their that could do something but the the blood levels of glucose would cause the clication

in the body i think that's probably more relevant the stuff that you're doing as you're eating it.

yeah you're gonna change the how those proteins look and there's all sorts of other issues with that because that binds to um reinflammatory receptors as well and the collocation advanced collocation in products i mean that can directly have an impact on the kidneys right.

yes so it's kind of funny when you take this full circle it's like.

okay protein is probably not problematic it's probably much more.

so the stuff that yeah the refined carbs and the other refined carbs we will surprise.

and i think maybe people get confused thinking that excess protein is going to contribute to higher levels of glucose which is not quite how it works.

and it's obviously a different path well together.

well the gluconia genesis stuff people are worried that you're going to have i think one thing i've heard is that it turns into fat.

i've heard that one too that the path from that you can have protein you too much protein you've turned into carbohydrate from glucanya genesis and then that can be turned into fat.

i think that that's not i mean i from the studies i've seen it seems like you're getting so glugany genesis is like fifteen percent effective like of the amount of turning protein into its very inefficient.

yeah it's a very inefficient process and then you we're talking about another process like so you got that the amount of carbage it has to survive and then make its way to the liver to be a sterified or has to be lengthened first and then a sterified so it's a very unlikely pathway and a very inefficient one.

so it's not impossible but just seems non appreciable like it's such a small amount that would that would occur.

it seems unlikely that that's ever gonna be an issue very much so demand driven versus just a supply thing it's not like you're eating a lot to prove even in akitos in a state you're not just magically.

i mean you're much more likely to take a trek glyceride glycerol backbone and turn that into that's gonna say too you're not even like.

yeah it's hard to glycerol is your main choke point.

·in a ketogenic diet because you're using up all the glycerol，you're making like it's just gonna get turned into glucose i think for them like it's you got to find the glucose somewhere right so it's like the backbones are the easiest place to to get it from using glister all to turn to glucose makes a lot of sense from what i've heard before it's excuse me from what i've heard before it's more about kind of how the i lose my voice more about how the protein essentially back burners some of the other substrates so maybe those other substrates can get sort of fat a little bit easier but it's not actually the protein and even then it has to be a lot and you have to be an ecloric surplus at that point for that to really right in effect yeah you're not going to you're not reasterifying fats unless there's a surplus yeah that's true as well all right dr jacob torus where can anyone find you my man i'm losing my voice up dr jacob torus coms easiest way to find me right on my man right man thanks cool！

来源：生酮饮食和轻断食