摘要：近年来，脑卒中治疗靶点研究取得多方面进展。铁死亡调控已成为脑卒中治疗靶点的热点，研究聚焦于铁代谢失衡和脂质过氧化机制，发现铁死亡抑制剂可通过阻断相关代谢通路减轻脑损伤，但临床转化需深入验证。
近年来，脑卒中治疗靶点研究取得多方面进展。铁死亡调控已成为脑卒中治疗靶点的热点，研究聚焦于铁代谢失衡和脂质过氧化机制，发现铁死亡抑制剂可通过阻断相关代谢通路减轻脑损伤，但临床转化需深入验证。
线粒体琥珀酰化修饰方面，Sirtuin 5介导的去琥珀酰化被证实可调节能量代谢、抑制氧化应激和神经炎症，增强其活性的药物在动物模型中显示出神经保护作用，但临床疗效待评估。分子伴侣在脑卒中后免疫抑制中的作用被揭示，其通过维持蛋白质稳态调节免疫反应，为降低感染风险提供新策略。
加巴喷丁类药物因其抗炎、抗氧化特性被探索用于脑卒中后神经修复及并发症管理，但疗效尚未明确，需更多临床试验支持。
此外，基因疗法在脊髓损伤中的成功（如促进轴突再生和运动功能恢复）为脑卒中治疗提供潜在方向，但其在脑卒中的应用仍需系统性研究。
总体而言，多靶点联合干预和转化研究是未来重点方向。为此，选择本刊学者2023-2024年发表的脑卒中的最新治疗靶点研究热点综述文章5篇，推荐读者阅读。
(1) Ferroptosis: a potential therapeutic target for stroke
铁死亡沉积：脑卒中的潜在治疗靶点
Chengli Liu 1, Guijun Wang 1, Wenrui Han 1, Qi Tian 1, Mingchang Li 1
1 Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
引用本文：
Liu C, Wang G, Han W, et al. Ferroptosis: a potential therapeutic target for stroke. Neural Regen Res. 2024;19(5):988-997.
正文链接：
(2) Succinylation modification: a potential therapeutic target in stroke
琥珀酰化修饰：脑卒中的潜在治疗靶点
Jie Lian 1, Wenwu Liu 2, Qin Hu 1, Xiaohua Zhang 1
1 Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
2 Department of Diving and Hyperbaric Medicine, Naval Medical Center, Naval Medical University, Shanghai, China.
引用本文：
Lian J, Liu W, Hu Q, et al. Succinylation modification: a potential therapeutic target in stroke. Neural Regen Res. 2024;19(4):781-787.
正文链接：
(3) Gabapentinoids for the treatment of stroke
治疗脑卒中的加巴喷丁类药物
Ying Zhang 1, Chenyu Zhang 1, Xiaoli Yi 1, Qi Wang 1, Tiejun Zhang 2, Yuwen Li 1
1 Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
2 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
引用本文：
Zhang Y, Zhang C, Yi X, et al. Gabapentinoids for the treatment of stroke. Neural Regen Res. 2024;19(7):1509-1516.
正文链接：
(4) The potential of gene therapies for spinal cord injury repair: a systematic review and meta-analysis of pre-clinical studies
脑部淋巴引流系统：缺血性脑卒中的新靶点？
Catriona J Cunningham 1, Mindaugas Viskontas 1, Krzysztof Janowicz 1, Yasmin Sani 1, Malin E Håkansson 1, Anastasia Heidari 1, Wenlong Huang 1, Xuenong Bo 2
1 Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK.
2 Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
引用本文：
Cunningham CJ, Viskontas M, Janowicz K, et al. The potential of gene therapies for spinal cord injury repair: a systematic review and meta-analysis of pre-clinical studies. Neural Regen Res. 2023;18(2):299-305.
正文链接：
(5) Molecular chaperones in stroke-induced immunosuppression
脑卒中诱导的免疫抑制中的分子伴侣
Haoduo Qiao 1, Qing Xu 1, Yunfei Xu 1, Yao Zhao 1, Nina He 1, Jie Tang 2, Jie Zhao 1, Ying Liu 1
1 Department of Neurosurgery, Xiangya Hospital, Central South University; Department of Pathophysiology, Xiangya School of Medicine, Central South University; Sepsis Translational Medicine Key Laboratory of Hunan Province; National Medicine Functional Experimental Teaching Center, Changsha, Hunan Province, China.
2 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
引用本文：
Qiao H, Xu Q, Xu Y, et al. Molecular chaperones in stroke-induced immunosuppression. Neural Regen Res. 2023;18(12):2638-2644.
正文链接：
来源：中国神经再生研究杂志
