摘要：Ye Wang, Wenyan Zhao, Dongcheng Zheng, Tiantian Liang, Jiali Qiu, Juan Zheng, Liang Liu,*and Fei Ye*
转自：康龙化成
Denitrative Iodination of Nitroarenes via Light-Promoted Reduction
Ye Wang, Wenyan Zhao, Dongcheng Zheng, Tiantian Liang, Jiali Qiu, Juan Zheng, Liang Liu,*and Fei Ye*
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction,
College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China.
—Org. Lett. 2025, DOI: https://doi.org/10.1021/acs.orglett.5c01222
Recommended by Chunlei Lu_ MC2 and Yuting Gao _ MC3
KEY WORDS: photo chemistry, denitrative iodination (反应类型), nitroarenes, 1,2-diiodoethane (原料), Aryl iodides (产物), C(sp2)-I (成键类型), transition-metal-free, Na2S2O3.5H2O (其他)
ABSTRACT: Aryl iodides are essential synthons in organic synthesis, whose conventional preparations often suffer from poor selectivity or necessitate multistep procedures. Herein, Ye & Liu’s group present a light-driven denitrative iodination as a one-step approach that directly converts nitroarenes to iodoarenes under mild and transition-metal-free conditions. Thisstreamlined method operates in the absence of strong Brønsted acids, ensuring broad functional group tolerance, including esters, cyanogroups, halides, and heterocycles, while also offering operational simplicity and scalability.
Substrates Scope
Control Experiments
Application
The Group of Pro. Fei Ye & Pro. Liang Liu has developed a light-promoted denitrativeiodination that efficiently converts nitroarenes into iodoarenes in a one-step approach under mild and neutral conditions, utilizing simple and readily available reagents, including sodium thiosulfate, water, nitrate salts, and 1,2-diiodoethane. It provides a practical and cost-effective alternative to conventional iodination strategies, offering broad functional group tolerance and operational simplicity. Given the prominence of aryl iodides in synthetic chemistry and biomedical applications, this transition-metal-free protocol provides a practical and sustainable alternative for their preparation.
来源：新浪财经
