摘要：Phyllanthin（叶下珠脂素）是一种存在于叶下珠属植物中的天然产物，可以显著降低Nrf2和AMPK水平，减少NF-κB的表达，具有抗氧化活性。

Phyllanthin（叶下珠脂素）是一种存在于叶下珠属植物中的天然产物，可以显著降低Nrf2和AMPK水平，减少NF-κB的表达，具有抗氧化活性。

化学性质

分子量 418.52

分子式 C24H34O6

CAS号 10351-88-9

溶解性（25°C） DMSO 55 mg/mL

储存条件 2-8°C, protect from light, sealed

运输方式 冰袋运输，根据产品的不同，可能会有相应调整。

储备液配制

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM 2.3894 mL 11.9469 mL 23.8937 mL

5 mM 0.4779 mL 2.3894 mL 4.7787 mL

10 mM 0.2389 mL 1.1947 mL 2.3894 mL

参考文献

[1] Honey Dzikri Marhaeny, et al. J Basic Clin Physiol Pharmacol. Phyllanthin and hypophyllanthin, the isolated compounds of Phyllanthus niruri inhibit protein receptor of corona virus (COVID-19) through in silico approach

[2] Hui Wang, et al. J Biochem Mol Toxicol. Phyllanthin inhibits MOLT-4 leukemic cancer cell growth and induces apoptosis through the inhibition of AKT and JNK signaling pathway

[3] Haitao Yuan, et al. J Environ Pathol Toxicol Oncol. Phyllanthin Averts Oxidative Stress and Neuroinflammation in Cerebral Ischemic-Reperfusion Injury through Modulation of the NF-κB and AMPK/Nrf2 Pathways

[4] Yulai You, et al. Biomed Pharmacother. Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells

[5] Cong Zhao, et al. Environ Toxicol. Cardioprotective role of phyllanthin against myocardial ischemia-reperfusion injury by alleviating oxidative stress and inflammation with increased adenosine triphosphate levels in the mice model

来源：AbMole