摘要:脊髓损伤后可导致神经功能障碍,严重影响患者的生活质量。目前修复策略的热点包括多模式治疗,特别是针对慢性完全性脊髓损伤、细胞移植和药物缓释支架的组合、细胞外囊泡的应用及其与其他治疗手段(如纳米粒子、药物和生物支架)的结合、以及针对脊髓微循环的药物干预,以此促进神
脊髓损伤后可导致神经功能障碍,严重影响患者的生活质量。目前修复策略的热点包括多模式治疗,特别是针对慢性完全性脊髓损伤、细胞移植和药物缓释支架的组合、细胞外囊泡的应用及其与其他治疗手段(如纳米粒子、药物和生物支架)的结合、以及针对脊髓微循环的药物干预,以此促进神经功能的恢复。这些策略旨在克服单一的修复方法所面临的局限性,并促进更全面、有效的功能恢复。为此,选择本刊学者2023-2024年发表的帕金森病发病机制的热点综述文章3篇,推荐读者阅读。
(1)Regenerative medicine strategies for chronic complete spinal cord injury
慢性完全性脊髓损伤的再生医学策略
Shogo Hashimoto 1, Narihito Nagoshi 2, Masaya Nakamura 2, Hideyuki Okano 3
Affiliations collapse
1 Department of Orthopedic Surgery; Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
2 Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan.
3 Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
引用本文:
Hashimoto S, Nagoshi N, Nakamura M, Okano H. Regenerative medicine strategies for chronic complete spinal cord injury. Neural Regen Res. 2024 Apr;19(4):818-824.
正文链接:
(2)Advances in extracellular vesicle-based combination therapies for spinal cord injury
基于细胞外囊泡的脊髓损伤综合治疗的进展
引用本文:
Wang T, Huang G, Yi Z, Dai S, Zhuang W, Guo S. Advances in extracellular vesicle-based combination therapies for spinal cord injury. Neural Regen Res. 2024 Feb;19(2):369-374.
正文链接:
(3)Pharmacological interventions targeting the microcirculation following traumatic spinal cord injury
针对创伤性脊髓损伤后微循环的药物干预措施
引用本文:
Wang R, Bai J. Pharmacological interventions targeting the microcirculation following traumatic spinal cord injury. Neural Regen Res. 2024 Jan;19(1):35-42.
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来源:中国神经再生研究杂志