摘要：中文别名Seco-Duocarmycin SA英文名称(S)-Seco-Duocarmycin SA英文别名Seco-Duocarmycin SA;(S)-Seco-Duocarmycin SA;(S)-Methyl 8-(chloroMethyl)-4-hy

中文别名
Seco-Duocarmycin SA
英文名称
(S)-Seco-Duocarmycin SA
英文别名
Seco-Duocarmycin SA;(S)-Seco-Duocarmycin SA;(S)-Methyl 8-(chloroMethyl)-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate;(8S)-8beta-(Chloromethyl)-4-hydroxy-6-(5,6,7-trimethoxy-1H-indol-2-ylcarbonyl)-3,6,7,8-tetrahydrobenzo[1,2-b:4,3-b']dipyrrole-2-carboxylic acid methyl ester;Methyl (8S)-8-(chloromethyl)-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrr
Cas No.
152785-82-5
分子式
C25H24ClN3O7
分子量
513.93
包装储存
Powder -20°C 3 years；In solvent -80°C 6 months

产品详情
(S)-Seco-Duocarmycin SA 是一种 DNA 烷化剂 (DNA alkylator)，可作为抗体药物偶联物的毒素部分 (ADC cytotoxin) 起作用。
生物活性
(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates.
性状
Solid
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years；In solvent -80°C 6 months
参考文献
[1]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69.

来源：趣聊健康密