医用聚焦超声技术:从基础到临床
效应类型物理参数生物学结果热效应温度>56℃持续1秒蛋白质变性,细胞即刻坏死机械效应声压>0.3 MPa细胞膜穿孔,促进药物渗透空化效应 |负压>5 MPa(惯性空化)微泡破裂产生冲击波声化学效应自由基生成速率>10^6/s增强化疗药物活性
效应类型物理参数生物学结果热效应温度>56℃持续1秒蛋白质变性,细胞即刻坏死机械效应声压>0.3 MPa细胞膜穿孔,促进药物渗透空化效应 |负压>5 MPa(惯性空化)微泡破裂产生冲击波声化学效应自由基生成速率>10^6/s增强化疗药物活性
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Shoji, S., Naruse, J., Ohno, S.et al.Focal therapy using high-intensity focused ultrasound with intraoperative prostate compressio