摘要：血管内皮损伤是多种心血管疾病如糖尿病全身血管纤维化、高脂血症及高血压等血管病变的始动因素。梁世杰主任提出的“血管内皮损伤修复方”通过中医辨证论治思想与现代药理研究成果的结合，为治疗这类疾病提供了新的思路。本文对方剂的组合规律、核心药材及其作用机制进行探索，旨在
摘要：血管内皮损伤是多种心血管疾病如糖尿病全身血管纤维化、高脂血症及高血压等血管病变的始动因素。梁世杰主任提出的“血管内皮损伤修复方”通过中医辨证论治思想与现代药理研究成果的结合，为治疗这类疾病提供了新的思路。本文对方剂的组合规律、核心药材及其作用机制进行探索，旨在揭示该方剂在治疗上述疾病中的物质基础与临床价值。
关键词：血管内皮损伤；中医辨证论治；梁世杰；处方研究
一、引言
血管作为人体血液运输的通道，其健康与通畅对人体生命健康至关重要。然而，由于高血压、高血脂、糖尿病等多种原因，血管内皮往往容易受到损伤，导致一系列心脑血管疾病的发生。梁世杰主任提出的“血管内皮损伤修复方”旨在通过中医药的整体调理与个体化治疗，有效修复血管内皮，预防并治疗相关血管病变。
二、方剂介绍
“血管内皮损伤修复方”由丹参15克、当归9克、黄芪15克、川芎10克、三七9克、桑叶10克、槐花10克、柏子仁15克、五味子6克、枸杞子9克、浮小麦15克、醋乳香6克、醋没药6克、儿茶5克、蒲黄10克、净山楂6克、炒杏仁10克、红花10克、蛇蜕6克、蝉蜕6克、僵蚕10克、胆南星6克、连翘3克等多种药材组成。该方剂融合了中医的活血化瘀、益气养阴、行气止痛等治法，旨在全面修复血管内皮，改善血管功能。
三、方剂组合规律与核心药材探索
1. 活血化瘀：丹参、三七、川芎、红花等药材具有显著的活血化瘀作用。丹参能破宿血，补新血，增加冠状动脉血流量，降低血液黏稠度，抑制血小板聚集，防止血栓形成。三七具有止血、散血、定痛的功效，对改善微循环、增加血管弹性有重要作用。川芎活血祛风止痛，红花则能活血通经，两者共同作用，可显著增强活血化瘀的效果。
2. 益气养阴：黄芪、当归、枸杞子等药材具有益气养阴的功效。黄芪补气升阳，利水消肿，对高血压、糖尿病等疾病对血管造成的损伤有保护和修复作用。当归补血活血，润肠通便，可改善气血运行，促进血管内皮修复。枸杞子则能滋补肝肾，益精明目，对保护心血管系统具有积极作用。
3. 行气止痛：柏子仁、醋乳香、醋没药等药材具有行气止痛的作用。柏子仁养心安神，润肠通便，对心绞痛等心血管疾病有一定疗效。醋乳香、醋没药则能活血止痛，消肿生肌，对缓解血管疼痛、促进血管修复具有显著效果。
4. 清热解毒：桑叶、槐花、连翘等药材具有清热解毒的功效。桑叶能疏散风热，清肺润燥，对高血压、糖尿病等引起的血管病变有辅助治疗作用。槐花则能凉血止血，清肝泻火，对改善血管功能、预防心血管疾病具有积极作用。连翘则能清热解毒，散结消肿，对炎症性血管病变有一定疗效。
四、作用机制及物质基础探索
1. 改善微循环：方剂中的丹参、三七、川芎等药材能够显著改善微循环，增加冠状动脉血流量，降低血液黏稠度，从而有效预防血栓形成，保护血管内皮免受损伤。
2. 调节血脂：黄芪、山楂等药材具有调节血脂的作用，能够降低低密度脂蛋白胆固醇和甘油三酯的含量，升高高密度脂蛋白胆固醇的含量，从而改善脂质代谢，减少脂质在血管壁上的沉积，预防动脉粥样硬化。
3. 抗氧化：方剂中的枸杞子、桑叶等药材富含抗氧化成分，能够清除自由基，减少氧化应激对血管内皮的损伤，保护血管细胞的正常结构和功能。
4. 抗炎作用：连翘、蝉蜕等药材具有抗炎作用，能够抑制炎症反应，减轻血管炎症性损伤，促进血管修复。
五、临床应用与案例分析
以糖尿病引起的全身血管纤维化为例，该疾病是糖尿病的一种严重并发症，可导致血管壁增厚、管腔狭窄，严重影响血液供应。通过应用“血管内皮损伤修复方”，可以显著改善患者的微循环障碍，降低血糖、血脂水平，减轻血管纤维化程度，从而延缓疾病进展，提高患者生活质量。
再以高脂血症患者为例，该疾病可导致脂质在血管壁上沉积，形成动脉粥样硬化斑块，增加心血管疾病的风险。通过服用该方剂，可以显著降低血脂水平，减少脂质沉积，稳定动脉粥样硬化斑块，预防心血管疾病的发生。
六、结论
梁世杰主任的“血管内皮损伤修复方”通过中医辨证论治思想与现代药理研究成果的结合，为治疗糖尿病引起的全身血管纤维化、高脂血症及高血压等血管病变提供了新的思路。该方剂通过活血化瘀、益气养阴、行气止痛、清热解毒等多种治法，全面修复血管内皮，改善血管功能，预防心血管疾病的发生。未来，我们将继续深入研究该方剂的作用机制及物质基础，为更多患者带来福音。
七、展望
随着中医药与现代医学的不断融合与发展，我们有理由相信，“血管内皮损伤修复方”将在心血管疾病的治疗中发挥更加重要的作用。同时，我们也期待更多的中医药研究能够取得突破性进展，为人类健康事业作出更大的贡献。让我们携手努力，共同推动中医药事业的发展与创新！
作者简介：梁世杰 中医高年资主治医师，本科学历，从事中医临床工作24年，积累了较丰富的临床经验。师从首都医科大学附属北京中医院肝病科主任医师、著名老中医陈勇，侍诊多载，深得器重，尽得真传！擅用“商汤经方分类疗法”、专病专方结合“焦树德学术思想”“关幼波十纲辨证”学术思想治疗疑难杂症为特色。现任北京树德堂中医研究院研究员，北京中医药薪火传承新3+3工程—焦树德门人（陈勇）传承工作站研究员，国际易联易学与养生专委会常务理事，中国中医药研究促进会焦树德学术传承专业委员会委员，中国药文化研究会中医药慢病防治分会首批癌症领域入库专家。荣获2020年中国中医药研究促进会仲景医学分会举办的第八届医圣仲景南阳论坛“经方名医”荣誉称号。2023年首届京津冀“扁鹊杯”燕赵医学研究主题征文优秀奖获得者。事迹入选《当代科学家》杂志、《中华英才》杂志。
"Blood vessels are clear, life is strong" - study by Dr. Shijie Leung on "reparative therapies for endothelial injury in blood vessels"
Abstract: Vascular endothelial injury is the initiating factor of many cardiovascular diseases such as diabetes mellitus, hyperlipidemia and hypertension. The "vascular endothelial injury repair prescription" proposed by Director Liang Shijie provides new ideas for treating such diseases through the combination of traditional Chinese dialectical treatment ideas with the achievements of modern pharmacological research. This paper explores the formulation pattern, the core ingredients and the Mechanism of action of the formulation, and aims to reveal the substance basis and clinical value of the formulations in the treatment of the above-mentioned diseases.
Keywords: endothelial injury of blood vessels; Dialectical therapy in Chinese medicine; Liang Shijie; Prescription Study
I. Introduction
Blood vessels act as channels for blood transport in the human body, and their health and smoothness are essential to human life and health. However, due to hypertension, hyperlipidemia, diabetes mellitus and other reasons, vascular endothelium is often vulnerable to injury, leading to a series of cardiovascular and cerebrovascular diseases. The "vascular endothelial injury repair recipe" proposed by Director Liang Shijie aims to effectively repair the endothelium of the blood vessels and prevent and treat related vascular lesions through the holistic conditioning and individualized treatment of Chinese medicine.
II. Introduction of formulations
"Vascular endothelial damage repair formula" consists of salvia miltiorrhiza 15g, angelica 9g, astragalus 15g, ligusticum chuanxiong 10g, 379g, mulberry leaves 10g, flos sophorae 10g, Chinese arborvitae kernel 15g, Schisandra 6 grams, 9 grams of barbary wolfberry fruit, floating wheat 15 grams, 6 grams of frankincense vinegar, vinegar myrrh 6 grams, catechu 5 grams, 10 grams of pollen typhae net hawthorn 6 grams, fried almond 10 grams, safflower 10 grams, snake exuviate 6 grams, cicada exuviate 6 grams, 10 grams of silkworm, gall 6 grams, 3 grams of forsythia and other medicinal herbs. The remedy incorporates the traditional Chinese medicine of active blood healing, qi tonic, qi relief, and pain relief, aiming to completely repair the endothelium of the blood vessels and improve their function.
III. The formulation rules and the exploration of core medicinal ingredients
1. Live blood healing: medicinal herbs such as Dan ginseng, San jian, chuan wei, and red flower have significant live blood healing effects. Salvia miltiorrhiza can break blood, fill new blood, increase coronary artery blood flow, reduce blood viscosity, inhibit platelet aggregation, prevent thrombosis. Thirty-seven has the effect of stopping blood, loosening blood, and fixing pain, and plays an important role in improving microcirculation and increasing blood vessel elasticity. Chonwen's live blood cures wind and pain, and redflowers can live blood and meridians, which together can significantly enhance the effect of live blood and bruises.
2. Replenishing qi and nourishing yin: astragalus, angelica, barbary wolfberry fruit and other herbs have the effect of replenishing qi and nourishing yin. Astragalus has the function of protecting and restoring the damage of blood vessels caused by hypertension and diabetes mellitus. When replenished blood live blood and lubricated the intestines and stool, it can improve air and blood flow and promote endothelial repair of blood vessels. Barbary wolfberry fruit can nourish the liver and kidney, Yijing eyesight, to protect the cardiovascular system has a positive role.
3. Gas pain: Chinese arborvitae kernel, vinegar frankincense, vinegar myrrh and other herbs have the role of gas pain. Chinese arborvitae kernel Yangxin sedative, Runchang catharsis, angina pectoris and other cardiovascular disorders have a certain effect. Vinegar frankincense, vinegar myrrh can promote blood circulation and relieve pain, reduce swelling and promote the repair of vessels.
4. Clearing heat and removing toxicity: mulberry leaves, sophora japonica, forsythia and other medicinal herbs have the effect of clearing heat and removing toxicity. Mulberry leaves can disperse wind-heat, clear lung and moisten dryness, and have auxiliary therapeutic effect on vascular diseases caused by hypertension and diabetes mellitus.槐 flowers can cool the blood and stop the blood, clear the liver and lay the fire, and have a positive effect on improving blood vessel function and preventing cardiovascular disease.Forsythia can be clearing heat and removing toxicity, dispersing mass and detumescence, inflammatory vascular disease has a certain effect.
IV. Mechanism of action and physical basis exploration
1. Improve microcirculation: Salvia miltiorrhiza, notoginseng, chuanxiong and other medicinal herbs can significantly improve microcirculation, increase coronary artery blood flow, reduce blood viscosity, so as to effectively prevent thrombosis, protect vascular endothelium from damage.
2. Regulating blood lipids: herbs such as calendula and hawthorn have the effect of regulating blood lipid, It can reduce the low density lipoprotein cholesterol and triglyceride, and increase the high density lipoprotein cholesterol.
3. Antioxidant: Barbary wolfberry fruit, mulberry leaves and other herbs in the formula are rich in antioxidants, which can clear free radicals, reduce oxidative stress damage to the vascular endothelial cells and protect the normal structure and function of blood vessel cells.
4. Anti-inflammatory effect: Forsythia suspensa, periostracum cicada and other medicinal herbs have anti-inflammatory effect, can inhibit inflammatory response, reduce inflammatory damage to promote the repair of vessels.
V. Clinical Applications and Case Analysis
For example, diabetes mellitus results in systemic vascular fibrosis, which is a serious complication of diabetes mellitus. It can significantly improve the disturbance of circulation, reduce the level of blood glucose and blood lipid, and alleviate the degree of vascular fibrosis.
Take the example of people with hyperlipidemia, which can cause lipids to deposit on the walls of blood vessels, forming atherosclerotic plaques and increasing the risk of cardiovascular disease. By taking this formulation, it is possible to significantly reduce blood lipid levels, reduce lipid deposition, stabilize atherosclerotic plaques, and prevent the occurrence of cardiovascular disease.
VI. CONCLUSIONS
Director Liang Shijie's "Vascular Endothelium Injury Repair Formula" provides a new way of thinking for the treatment of diabetes mellitus caused by vascular fibrosis, hyperlipidemia and hypertension. It can improve the blood vessel function by activating blood circulation to remove blood stasis, replenishing qi and nourishing yin, activating qi to relieve pain, clearing heat and removing toxicity. In the future, we will continue to delve into the mechanism of action and the physical basis of this formulation to bring benefits to more patients.
VII. Looking ahead
With the continuous integration and development of traditional Chinese medicine and modern medicine, we have reason to believe that "vascular endothelial injury repair remedies" will play an even more important role in the treatment of cardiovascular disease. At the same time, we also expect more traditional Chinese medicine research to make breakthroughs and make greater contributions to the cause of human health. Let us work together to promote the development and innovation of traditional Chinese medicine.
Author Bio: Liang Shijie is a senior medical practitioner in traditional Chinese medicine with an undergraduate degree. He has been engaged in traditional medicine clinical work for 24 years and has accumulated a wealth of clinical experience. Following Chen Yong, chief physician of liver disease at Beijing Traditional Medicine Hospital, affiliated with Capital Medical University, and renowned old Chinese medicine, he has been treated for many years and received great attention. He specializes in the treatment of difficult diseases using "conversational traditional therapy" and special treatments combined with the academic ideas of Jiao Shude and Guan Yubo's ten-level diagnosis.He is currently a researcher at the Shude Tang TCM Research Institute in Beijing, a fellow at the new 3 + 3 project of traditional Chinese medicine flame inheritance in Beijing - a scholar at the inheritance workstation of Jiao Shude's protégés (Chen Yong),He is a standing committee member of the International Expert Committee on E-learning and Health Care, a member of the Jiao Shude Academic Heritage Special Committee of the Chinese Association for the Advancement of Chinese Medicine Research, and the first cancer specialist to be included in the chapter of the Chinese Pharmaceutical Culture Research Association. Won the 2020 China Association for the Promotion of Traditional Chinese Medicine Zhongjing Medical Branch held the eighth session of the Medical Saint Zhongjing Nanyang Forum "Classic Prescription Famous Doctor" honorary title. The winner of the first Beijing-Tianjin-Hebei "Pingui Cup" Yanzhao Medical Research Essay Award in 2023. His work was featured in the journal Current Scientist and the journal Chinese Talent.
来源：首都专家梁世杰一点号
