衰老与神经系统疾病的关系：NRR热点话题

摘要：衰老是神经系统疾病的主要风险因素，与神经退行性疾病（如阿尔茨海默病）密切相关。衰老过程中，神经元的细胞骨架（如微管）逐渐不稳定，导致突触功能下降、神经元形态改变以及神经信号传导能力减弱。

衰老是神经系统疾病的主要风险因素，与神经退行性疾病（如阿尔茨海默病）密切相关。衰老过程中，神经元的细胞骨架（如微管）逐渐不稳定，导致突触功能下降、神经元形态改变以及神经信号传导能力减弱。

此外，衰老伴随的慢性炎症和小胶质细胞的失调会加剧神经退行性疾病的进展，而昼夜节律和下丘脑功能的紊乱则进一步削弱神经系统的稳定性，这些变化不仅增加了神经系统疾病的发生风险，还导致认知和行为功能的衰退。

因此，研究衰老过程中神经系统的分子和细胞机制，对于理解疾病发生机制和开发干预策略具有重要意义。为此，选择本刊学者2023-2024年发表的衰老与神经系统疾病研究热点综述文章5篇，推荐读者阅读。

(1) How do neurons age? A focused review on the aging of the microtubular cytoskeleton

神经元是如何衰老的？微管细胞骨架老化的重点综述

Brad Richardson 1, Thomas Goedert 2, Shmma Quraishe 1, Katrin Deinhardt 1, Amritpal Mudher 1

1 School of Biological Sciences, University of Southampton, Southampton, UK.

2 Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.

引用本文：

Richardson B, Goedert T, Quraishe S, et al. How do neurons age? A focused review on the aging of the microtubular cytoskeleton. Neural Regen Res. 2024;19(9):1899-1907.

正文链接：

(2) Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases

神经退行性疾病发展过程中微粒体对衰老和神经炎症的反应

Tingting Han 1, Yuxiang Xu 1, Lin Sun 1 2, Makoto Hashimoto 3, Jianshe Wei 1

1 Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng, Henan Province, China.

2 College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan Province, China.

3 Department of Basic Technology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

引用本文：

Han T, Xu Y, Sun L, Hashimoto M, Wei J. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural Regen Res. 2024 Jun 1;19(6):1241-1248.

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(3) Hypothalamic circuits and aging: keeping the circadian clock updated

下丘脑回路与衰老：更新昼夜节律表

Rosa Vázquez-Lizarraga 1, Lucia Mendoza-Viveros 1 2 3, Carolina Cid-Castro 1 2 3, Sareni Ruiz-Montoya 1, Erick Carreño-Vázquez 1, Ricardo Orozco-Solis 1 2

1 Instituto Nacional de Medicina Genómica (INMEGEN), México City, México.

2 Centro de Investigacíon sobre el Envejecimiento, Centro de Investigacíon y de Estudios Avanzados (CIE-CINVESTAV), México City, México.

3 Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México UNAM, México City, México.

引用本文：

Vázquez-Lizarraga R, Mendoza-Viveros L, Cid-Castro C, et al. Hypothalamic circuits and aging: keeping the circadian clock updated. Neural Regen Res. 2024;19(9):1919-1928.

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(4) Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

衰老中长非编码RNA的分子特征及其对衰老相关疾病的重要影响

引用本文：

Sherazi SAM, Abbasi A, Jamil A, et al. Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases. Neural Regen Res. 2023;18(5):959-968.

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(5) Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

是否旁观者？衰老和脑卒中的小胶质细胞和淋巴细胞

Luigi Manni 1, Giorgio Conti 2, Antonio Chiaretti 3, Marzia Soligo 1

1Institute of Translational Pharmacology, National Research Council of Italy (CNR), Rome, Italy.

2Intensive Pediatric Therapy and Pediatric Trauma Center, Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

3Institute of Pediatrics, Department of Woman and Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

引用本文：

Manni L, Conti G, Chiaretti A, et al. Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury. Neural Regen Res. 2023;18(4):773-778.

正文链接：https://journals.lww.com/nrronline/fulltext/2023/04000/intranasal_nerve_growth_factor_for_prevention_and.12.aspx