摘要：Docosahexaenoic Acid (DHA)是丰富地存在于脑和视网膜中的ω-3脂肪酸，对婴儿大脑的生长和功能发育至关重要。DHA 也是维持成人正常大脑功能所必需的。DHA 还是一种有效的 RXR 激活剂。

Docosahexaenoic Acid (DHA)是丰富地存在于脑和视网膜中的ω-3脂肪酸，对婴儿大脑的生长和功能发育至关重要。DHA 也是维持成人正常大脑功能所必需的。DHA 还是一种有效的 RXR 激活剂。

生物活性

Docosahexaenoic acid is a endogenous omega-3 fatty acid. Docosahexaenoic Acid (DHA) acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Docosahexaenoic Acid (DHA) activates all three RXR isoforms. DHA also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling.

Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex.

In Vivo Experimental (Only for reference)

Male C57BL/6mice (10 months old, weighing 25–30 g) were randomly divided into four experimental groups as follows: control (n = 15); DHA-treated (DHA) (n = 15); MPTP-injected (MPTP) (n=15), and DHA-treated+MPTP-injected (MPTP+DHA) (n=15). Docosahexaenoic acid was dissolved in corn oil at a concentration of 0.046 M and was given to the treatment groups for 30 days (36 mg/kg/day) by gavage.

化学性质

分子量：328.49

分子式： C22H32O2

CAS号： 6217-54-5

溶解性：（25°C） DMSO 70 mg/mL

0.1 M NaOH: 6 mg/mL

储存条件： -20°C, protect from light, sealed

运输方式： 冰袋运输，根据产品的不同，可能会有相应调整。

储备液配制

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM 3.0442 mL 15.2212 mL 30.4423 mL

5 mM 0.6088 mL 3.0442 mL 6.0885 mL

10 mM 0.3044 mL 1.5221 mL 3.0442 mL

参考文献

[1] Bosmans, et al. Mol Pharmacol. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.

来源：AbMole